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Trihexyphen (Trihexyphenidyl)

The investigation of the metabolism of the antiparkinson drugs Trihexyphen (1), pridinol (2) and biperiden (3) revealed a graduate tendency for hydroxylation in the different structural elements: If alicyclic, saturated heterocyclic and aromatic ring systems are present in one compound like in 1, the alicyclic ring system is attacked predominately.

Other names for this medication:
Trihexyphenidyl, Artane, Benzhexol, Broflex, Cyclodol, Hexymer, Hipokinon, Pacitane, Pargitan, Parkan, Parkisan, Parkizol, Parkopan, Rodenal, Romparkin, Tonaril, Trihexifenidilo, Trihexy, Trihexyphen,

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Trihexyphen is used along with other medications to treat the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and to control extrapyramidal symptoms (tremor, slurred speech) caused by certain medications. Trihexyphen is in a class of medications called antimuscarinics. It works by relaxing muscles and nerve impulses that control the function of muscles.

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The patient had an excellent therapeutic response with no clinically apparent basal cell carcinomas for 18 months. The use of mammalian cultured cells loaded with a fluorescent dye shows specific membrane penetration of undissociated acetic acid. It is concluded that the experimental pain increased the arousal level thus counteracting morphine-induced sedation.

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This important redox system is believed to be driven by an enzyme or enzyme complex involving a multicopper oxidase, although the biochemical mechanism has never been conclusively demonstrated. In contrast, membrane-bound human IgM and mouse IgM, IgD and Thy-1 antigen were not labelled on the inner membrane surface. The hormonal induction of a vaginal leukocytic exudate in the germ-free mouse. Long-term surveillance requires considerable logistic effort at GCCR and requires that thousands of letters be mailed each year in order to ensure regularly updated information.

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Endoscopic surgery for fronto-ethmoidal mucoceles: a 15-year experience. Studies on the fungal flora in the lung of human necropsy cases. Dispersed cells from mouse pancreata and hypothalamus were used in conjunction with the insulin-secreting cell line MIN6. It seems that patients with PKD who had normal GFRs retain rather than waste sodium and may become hypertensive. A group of 5 selected malignant meningiomas was studied in relation to the incidence and morphology of the mitoses.

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mGluR1 expression began to decline in the perikarya 2 days postlesion and a day later in the neuropil. Determination of anions, cations and organic acids in the oil field water by ion chromatography

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An intravenous introduction of its high doses was followed also by a fall of the total arterial pressure. Using multiple statistical methods, 546 significantly differentially expressed probe sets were identified. A donor Peptostreptococcus anaerobius strain carrying the three determinants could transfer Tet M to P. The establishment of such a predictor will no doubt expedite the functionality determination of newly found proteins and the process of prioritizing genes and proteins identified by genomics efforts as potential molecular targets for drug design. Major risk stratification models do not predict perioperative outcome after coronary artery bypass grafting in patients with previous percutaneous intervention.

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Morphological, biological, and serological properties of newly isolated temperate phages of Lactobacillus salivarius. For the anterior face height (nasion-gnathion) and the posterior face height (sella-gonion) a fourth degree polynomial was fitted.

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Clinical evaluation of some restorative materials for anterior teeth. Based on the available literature, we suggest that this gene lineage possesses stress-related biological functions (e.g., response to UV light, pathogen defense).

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In the neocortex, spike-timing-dependent long-term depression (LTD) requires simultaneous activation of presynaptic NMDA autoreceptors and retrograde signalling by endocannabinoids. Thermodynamics of weakly coupled Falicov-Kimball chains from renormalization-group theory. The vessel phantoms were insonified at 32 MHz with an ultrasound biomicroscope to provide cross-section sequences of radio-frequency (RF) ultrasound data. Beyond the difficulties in reaching homes with OPV, challenges for vaccination programmes in higher-conflict areas extend to limited awareness, negative attitudes, and gaps in trust.

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Large aspirin doses have not been associated with proportionally greater benefit. Furthermore, when the equivalence ratio is greater than unity by even a slight amount, the degree of chlorination of product gases increases markedly when the Cl/H ratio also exceeds unity. Tetrachloroethylene and piperazine in the combined treatment of necatoriasis, ascariasis and trichuriasis

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We find that the distribution of retrogenes in the Drosophila melanogaster genome can be explained by an insertion bias toward chromosome domains containing testis-biased genes that are located at the nuclear periphery in somatic cells, but at inner positions in the male germ line. Progress in pharmacotherapy of pulmonary arterial hypertension in children

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Articles were selected for inclusion on the basis of targeted keyword searches, manual review of bibliographies, and whether the article was a clinical trial, large observational study, or retrospective study focusing on melanoma brain metastases. Morphologically, the low density cells exhibited typical features of aortic foam cells. The successful surgical repair of a ruptured interventricular septum following a myocardial infarct in an 89 year old man.

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Stimulation of mitosis in rat marrow cultures by serum from infected rats. The purpose of this study was to evaluate the efficacy of sonography to rule out the presence of a pneumothorax in the trauma population. Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease. Based on vegetations attached to the mitral valve by echocardiography and positive blood cultures for Streptococcus mitis, the diagnosis of IE was made at the referring hospital. The aim of the present study was to evaluate our results after anatomic primary repair.

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Do female medical graduates have different views on professional work and workload compared to their male colleagues? In eight anaesthetized 1-2 day old piglets rectal, tympanic and scalp temperatures were monitored continuously. Furthermore, we employed the luciferase reporter system and chromatin immunoprecipitation (ChIP) to demonstrate that MEF2A does in fact bind the regulatory region of HZF1, which suggests that HZF1 is the direct target of MEF2A. Many outbreaks in humans have been reported, most often among children and neonates. Results of this study indicated that oxidation of lipids occurred in pan-fried Zousoon after prolonged storage.

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We compared EQ-5D, SF-36, quality of life After MI (QLMI), and Canadian Cardiovascular Society Anginal Classification (CCSG) scores. Role of intestinal microbes in body composition in germ-free, gnotobiotic and conventional mice. The embedding problem is the distance geometry equivalent of the multiple minima problem, which arises in energy minimization approaches to conformation determination. The endosymbionts are essential for the survival of the aphid hosts. gingivalis-infected OSCC cells was correlated with enhanced production of matrix metalloproteinase (MMP)-1 and MMP-10 that was stimulated by interleukin-8 (IL-8) release.

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It was found that most of the concentrations of trace metals, including rare earth elements (REEs), in JSAC 0301-1 were lower than those in JAC 0031, which was also a previously issued CRM prepared with water from the same river as that of JSAC 0301-1. The current study examined whether the implementation of a reminder system improved screening rates. Post-myocardial infarction polymorphous ventricular tachycardia is not consistently related to an abnormally long QT interval, sinus bradycardia, preceding sinus pauses, or electrolyte abnormalities. The number of Ki-67 (proliferating cell marker)- and doublecortin (immature progenitor neuron marker)-positive cells were significantly time- and dose-dependently changed in the dentate gyrus of adult hippocampi after MTX treatment. These findings suggest that REMSD increases nociceptive sensitivity under conditions of sustained, selective C nociceptor activation (42 degrees C), but not under conditions of phasic A-delta activation (52 degrees C).

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The reader should understand the differences between performing a root canal treatment in teeth with vital pulps and those with infected root canal spaces and peri-radicular pathology. Cavernous Hemangioma of the Choroid: Report of Five Cases in the Registry of Ophthalmic Pathology, Army Medical Museum, Washington, D. Previous findings had already shown that a mutation in the XlnR C-terminal region resulted in transcription of the structural genes under non-inducing conditions. Comparative and functional genomics have fundamentally improved our understanding of their modes of adaptation to different ecological niches and the genes that determine their pathogenicity. Serum neutralization titers were obtained prior to and 3 weeks post-inoculation (PI).

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The aim of this study was to evaluate the long-term surveillance and treatment outcomes of MGC after curative gastric ESD. Nuclear symptoms of schizophrenia after cingulotomy: a case report. Herkogamy and mate diversity in the wild daffodil Narcissus longispathus: beyond the selfing-outcrossing paradigm in the evolution of mixed mating. It is currently assumed that Nedd4 and Tsg101 represent equivalent entry gates towards the same cellular process leading to budding, and that both partners are recruited to the plasma membrane where viral budding occurs. Computed and nuclear magnetic resonance tomography in the diagnosis of diseases and injuries of the temporomandibular joint

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Significant differences in the prevalence of insomnia symptoms and current sleeping problems with respect to ethnicity have implications in the purchase and development of treatment services, with greater need for these services among Maori than non-Maori. The feasibility and efficacy of fluorescence diagnosis for localization of parathyroids has already been proven in an experimental setting. In the boys with 4-cusped mandibular first molars, the mineralization of the teeth occurred at significantly earlier chronological and skeletal ages when they were significantly shorter in stature. Histopathology of experimental infections induced by infections with enteric neurotropic viruses In addition, evidence of selection near a homologous locus of FAR1 concurred with sorghum phenotypic diversity for sensitivity to photoperiod.

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Additionally the fragmentation mechanism of the cationic N-hydroxypropyl-N,N,N-trimethylammonium group during electrospray ionization was investigated. Expression analysis of genes involved in collagen cross-linking and its regulation in traumatic anterior shoulder instability. Immuno-electromicroscopic studies were performed with a mAb which revealed that the 150-kDa antigen was localized to the cell surface of W.

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To determine the role of CIRP in DNA damage-induced apoptosis, we performed CIRP overexpression and knockdown experiments to investigate the effects of CIRP on key molecules in apoptosis pathway. 39 postmenopausal women, who were taking local estrogen therapy for at least 6 months, were examined in the study group. However, diazepam had greater peak effects on performance measures (simple reaction time, digit symbol substitution task, and cancellation time) in methadone-treated than in buprenorphine-treated patients.

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Furthermore, we develop a phase space representation, focusing on the inputs to and the intrinsic slow variable of the knee extensor motoneuron, which we use to derive sufficient conditions for the network to realize each rhythm and which illustrates the role of a saddle-node bifurcation in achieving the knee extensor delay. Basic advantage to the physician is that clients selecting natural methods can be referred to natural family planning centers for instruction and follow-up.

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High affinity binding of Lys20 was completely blocked by 2R-B mAb recognizing IL-2R beta-chain. Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling. Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii.

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The inventory described the plant parts used, their mode of preparation, and their therapeutic uses. The key finding in histopathology was a distinctive pattern of ACIF centered on membranous and respiratory bronchioles.

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Relationship between medical expenses for the aged residing in farming villages and a social support network--documentation using details of medial expenses This post-mortem approach, however, is not suitable for investigating the diet of rare or protected species and also prohibits tracking individual dietary preferences as each consumer can provide trophic information only once. Since the hydrazinolyzate is a polysaccharide incorporated with cysteine, it was S-derivatized with a thiol-specific fluorogenic reagent, 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABD-F). Two recent studies show that silencing of FoxO1 is also essential for extra-hepatic insulin signaling to maintain glucose homeostasis.

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If the N-3 host specificity is imparted by cytosine methylation, this would be the first instance where a biological role for 5MeCyt has been elucidated. Our results demonstrated that clustered variables were characterized by common genomic regions. Traumatic brain injury produced equivalent acute hypertension and increased plasma glucose levels in both young adult and aging rats.

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Mutagenesis of Tyr or Trp at the corresponding locations in Sites 3 and 5 did not lead to a reduction in activity. In vitro expression studies demonstrated that this mutation results in reduced ligand binding and signal transduction of the receptor.

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In recent studies we have demonstrated that viruses and bacteria share amino acid sequences with the human proteome at such a high extent that the molecular mimicry hypothesis becomes questionable as a causal factor in autoimmunity. The lack of prospective data and more complete outcome assessment has been, at least in part, responsible for the marked difference in opinions between rheumatologists and hand surgeons on the effectiveness of MCP arthroplasty. z-Ions that were terminated with a deaminated phosphoserine radical competitively eliminated phosphoric acid and H(2)PO(4) radicals. A new MLKAFO (sliding-type MLKAFO), which uses sliding medial linkages, has been developed to correct the axial discrepancy of the hinge-type MLKAFO that causes limited hip joint excursion. We conclude from these data that PTEN can modulate the expression level of a number of different proteins.

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Thirty-one patients had relief of pain for 8 to greater than 40 hours, averaging 18 hours. Bridging therapies and liver transplantation in acute liver failure, 10 years of MARS experience from Finland. Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells. Possibility of change in the predominant type of electrogenesis in myocardial cells of the frog Rana temporaria due to the effect of bivalent cations

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However, palpability and possibility for secondary operation for plate removal were shortcomings. The pineal complex of rodents is made up of a pineal gland which developmentally always originates from the area between the habenular and posterior commissure and a pineal sac which is continuous with the choroid plexus of the third ventricle.

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The Dutch protocol for rehabilitative management was developed to provide an optimal and adequate care plan for patients with ALS. Late return of renal function after correction of chronic obstruction. The D-galactose exposure also induced an increase in peripheral oxidative stress, including an increase in malondialdehyde, a decrease in total anti-oxidative capabilities (T-AOC), total superoxide dismutase (T-SOD), and glutathione peroxidase (GSH-Px) activities. To estimate the prevalence of hypocalcemia in children examined for serum calcium. Using this method, we confirm and expand previous studies showing that NSCs in distinct walls of the LV produce neurons that invade different layers of the OB.

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The number and types of medical visits were compared between CAM and non-CAM users. Contrary to short-term use, long-term benzodiazepine use is undesirable. Ultrasonic and exercise therapy in complex management of patients with peptic ulcer Activation of p38 has opposing effects on the proliferation and migration of endothelial cells. In this field, prospective controlled outcome registries may provide a control for over- and faulty regulation.

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This may be as a result of non-collagenous components in the artery becoming more easily damaged than the collagen fibres during loading. Apart from the self-evident necessity of an exact reconstruction of joint faces (more often than before conditioning the indication for arthrotomy) timely mobility can be reached by only adapting osteosynthesis, as in this region there is virtually no pseudoarthrosis. As such, surgical treatment of cor triatriatum remains the mainstay of treatment in adult patients, especially when other cardiovascular anomalies are present which require surgical correction. A total of 1,355 patients (418 women) who underwent a single-photon emission computed tomography treadmill exercise stress test and had not experienced a cardiac event in the past 2 weeks participated in the current study. Consequently, we have developed an automated method that allows unattended identification and quantification of lipid molecular species of all the major lipid classes from a two-dimensional chromatographic/mass spectrometric data set.

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Acyclovir prophylaxis to prevent herpes simplex virus recurrence at delivery: a systematic review. In our opinion, pulmonary placental transmogrification is not a variant of emphysema, as generally considered, but rather probably represents a benign proliferation of immature interstitial clear cells with secondary cystic change. The test proteins selected were Bax, which acts at the level of the mitochondria, and caspase 3, which is the major executioner protease. A newly identified subset of T-cells with immunoregulatory functions, CD1d-restricted natural-killer T (NKT) cells, has been shown to protect against disorders with increased CD4-positive Th1 responses in animals. Prediction of the condensed phase heat of formation of energetic compounds.

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It is unlikely that ground-based pre-habituation to linear accelerations of the type examined would alter susceptibility to space motion sickness. Evaluation of medical staff and patient satisfaction of Chinese hospitals and measures for improvement. In this case, combined therapy has better results than monotherapy.

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Extrapolating the trial results to the distribution in the provincial screening program, implementation of either HPV or LBC throughout the provincial population would approximately double the normax tabletten dispenser current rates of referral for colposcopy. The compounds demonstrated sub-nanomolar in vitro IC(50) values, minimal activity shifts in pure plasma and improved pharmacokinetics.

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The incidence of ARF has decreased to 30 per 100,000 in 2005, 12.8 per 100,000 in 2007, 7.3 per myodura tablet 100,000 in 2008, and 9.5 per 100,000 in 2009. The results indicated interesting antiproliferative activity and significant apoptosis induction. porrum, while the fruits of Solanum incanum showed the least activity.

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Mouse blood monocytes: standardizing their identification and analysis using CD115. Data were collected by means of self-administered questionnaires containing questions about sociodemographic variables, characteristics of the complaints, and several intraindividual and extraindividual factors, including several psychosocial variables (e.g., pain coping, distress, and kinesiophobia). In vivo, CPT treatment sensitized mice to TNF-induced hearthstone rock vs flamygel liver damage. Addition of mutant K6a-specific siRNA resulted in inhibition of mutant, but not WT, K6a/reporter expression.

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To address these issues, we developed the curved periacetabular osteotomy, a modification of the Bernese periacetabular osteotomy which limits dissection, prevents the outside of the ilium from being exposed, and aurobindo pharma usa simvastatin vs atorvastatin produces osteotomy surfaces with the same curvature. Lowest comorbidity associations were found for specific phobia and alcohol abuse-the disorders with the least functional disabilities.

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One of the newer molecular targets that has been exploited in the search for better drug candidates is HCMV protease. Selective reaction of semiconducting carbon nanotubes was achieved by preorganizing the starting N-oxides on the nanotube surface prior to generating the reactive ylides. Effects of detomidine on equine oesophageal function as studied by contrast radiography. This strategy was applied to mRFP1, which was converted into probes that are photoactivated by either green or violet light. Total mortality from 1981 to 2009 among individuals with complete data on job strain in midlife, categorised according to job demand and job control: high job strain (high job demands and low prophylactic acyclovir dose in pregnancy job control), active job (high job demand and high job control), passive job (low job demand and low job control) and low job strain (low job demand and high job control).

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This cyclization provides an easy and convenient synthesis of complex benzenes bearing various different substituents. Improved respiratory system conductance following bronchodilator predicts reduced exertional dyspnoea. Pancreatic cancer is a notorious disease with a dicloran tablets used for poor prognosis and low survival rates, which is due to limited advances in understanding of the molecular mechanism and inadequate development of effective treatment options over the decades. In order to broaden our knowledge of this area, we have reviewed and summarized clinical studies that reported clearance values of drugs in both obese and non-obese patients.

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The goal of this study was to determine the effects of partial weight bearing on the loading of the healing bone in tibial osteotomies. The Norwegian zorax company names sheep breeding scheme: description, genetic and phenotypic change.

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A nationale programme for combatting cardiovascular diseases is being implemented in Letvia. Based on our results we suggested an algorithm for management of IPF patients presenting with acute respiratory failure. Suppression of Smad3 expression in mast cells may thus have therapeutic potential for Gram-negative bacterial infection such as acute septic peritonitis by augmenting innate immune responses of mast cells. Metabolic engineering with Dof1 transcription factor in plants: Improved nitrogen assimilation and growth zolt info solutions written test papers under low-nitrogen conditions.

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Their biology is relatively well known in the Palaearctic, though other regions are poorly known, and there are no associations recorded between mycetophilid immatures and fungi in the Neotropical region. PT could be done within 7 hours without influence to the result if the plasma was stored with the packed cells at 4 degrees C. Here we summarize recent insights gathered from a combination of structural, biochemical, and cell biological studies that have revealed a remarkable complexity of the machinery for endocytic sorting and membrane deformation. Apparent birefringence data obtained from multi-angle measurements using a time domain polarization-sensitive optical coherence tomography system has been compared with simulated data based on the extended Jones matrix calculus. Preoperative zytanix action research assessment of the hyomental distance ratio may predict difficult laryngoscopy resulting in difficult intubation.

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Treatment of unilateral ostan gweedore reviews of spirit acute sixth-nerve palsy with botulinum toxin. There was significant improvement in popliteal angle, fixed knee flexion contracture, knee angle at foot contact (FC), and mid-stance knee extension after HL. The chemically heterogeneous pattern consists of different adsorption sites specifically distributed on a surface.

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These distinctive patterns la tenace schuhe kaufen online of distribution suggest that these channels are likely to have different biological functions and could be specifically targeted for a number of human diseases, such as irritable bowel syndrome, hypertension and erectile dysfunction. Anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibodies, such as ipilimumab, have generated measurable immune responses to Melan-A, NY-ESO-1, and gp100 antigens in metastatic melanoma. Immobilization of lead and zinc in scrubber residues from MSW combustion using soluble phosphates.